Lake Eyre ( AIR), officially known as Kati Thanda–Lake Eyre, is an endorheic lake in the east-central part of the Far North region of South Australia, some 700 km (435 mi) north of Adelaide. The shallow lake is the depocentre of the vast endorheic Lake Eyre basin, and contains the lowest natural point in Australia, at approximately 15 m (49 ft) below sea level. On the rare occasions that it fills completely, it is the largest lake in Australia, covering an area of up to 9,500 km² (3,668 sq mi). When the lake is full, it has the same salinity as seawater, but becomes hypersaline as the lake dries up and the water evaporates.

The lake was named in honour of Edward John Eyre, the first European to see it in 1840. It was officially renamed in December 2012 to include its Aboriginal name, Kati Thanda, in accordance with a policy of dual naming. The native title over the lake and surrounding region is held by the Arabana people.